Access is denied.
I recently had a single citrix user who began receiving this error when attempting to run an streamed application from one of my citrix farms.
I began researching the error and, as per the norm, the citrix user forums were less than helpful. They included the norms of "Install hotfix X from citrix, service pack Y from Microsoft" and the like.
I tell ya, I wish I had a dollar for every hotfix citrix said to install that in the end did not solve the issue... but I digress. 🙁
At any rate, I began looking at another application and noticed it was running without issue. Diffing further, I noticed that the successful application was setup to run on only one server. I configured the failing application to run on that server as well and, wow, it worked.
All of my servers are configured the same, so this was perplexing until I ran across a thread that mentioned corrupt profiles.
I deleted the users profile on the servers where the application was failing and everything began working properly.
This was odd as the issue was occurring for a while and I reboot the servers nightly and purge all user profiles so I would have thought that it would have cleared on its own.